Dr. Gaurav Jerath

About

I started my research journey in the field of Computational Network Systems Biology. In later years, my work developed in the fields of protein biophysics, biochemistry and chemical biology. I earned my doctorate from the department of Biosciences and Bioengineering at Indian Institute of Technology Guwahati.
At GBU, I lead a group of young and dynamic researchers who strive towards the development of therapeutics for the treatment multi-factorial complex diseases like cancer, hypertension, diabetes, obesity and auto-immune disorders.
We are an interdisciplinary research group which integrates the principles of biology with chemistry, physics and mathematics to bridge the gap between a laboratory bench and applied clinical solutions. Though, majority of our work is translational in its nature, our lab also works in understanding these diseases at a systems level.

The Biomolecular Systems Laboratory: Engineering Biological Systems

The laboratory operates at the cutting-edge convergence of computational biology, chemical biology and network medicine to decode disease complexity and engineer precision interventions.

The research group primarily works in four verticals:

1. Development of peptide-based targeted delivery vectors for the treatment of different cancer types and autoimmune diseases.
2. Development of bioactive peptides as therapeutics for treatment of Diabetes, Obesity, Hypertension and Neurodegenerative diseases.
3. Understanding diseases complexity of cancer and cardio-metabolic diseases using the principles of Network Biology for development of Network Medicine.
4. Mathematical Modeling and Computational Biophysics.

Lab Members:

1. Ms. Khushi Parmar, PhD Scholar
2. Ms. Meshwa Barot, Junior Research Fellow
3. Mr. Aryan Thakur, M.Sc. 2nd Year Dissertation Student
4. Ms. Dimple Sharma, M.Sc. 2nd Year Dissertation Student
5. Mr. Rohil Chaudhary, M.Sc. 2nd Year Dissertation Student

Positions at Lab:
I am actively recruiting highly motivated Ph.D. students. If you are intellectually fearless, resilient, and excited about the interdisciplinary research at our lab, please email me with your CV and a brief description of a scientific problem you are passionate about solving.
For project openings, refer to the University’s website and social media handles.

Past Members:
M. Sc. Dissertation Students (Graduated)

1. Ms. Suranjana Ray Chaudhuri
2. Ms. Anagha M.
3. Ms. Anushi Shah
4. Mr. Amitkumar Prajapati, PhD Scholar at IISER Pune
5. Ms. Vrutika Joshi
6. Ms. Honey Parekh, Zydus Lifesciences Ltd.
7. Ms. Meshwa Barot, JRF at GBU
8. Ms. Zeel Patel, PhD Scholar at ACTREC, Tata Memorial Centre
9. Mr. Adit Kotak, o2h Discovery Pvt. Ltd.
10. Ms. Bhawana Jain, Founder- Bawra Digitals Pvt. Ltd.
11. Ms. Khushi Parmar, PhD Scholar at GBU
12. Ms. Neha Padhi, PhD Scholar at NIT Rourkela

Teaching:
1. Omics for Medical Sciences
2. Introduction to Mathematical Modeling for Biological Systems

Ongoing Extramural Projects:
1. Stereochemically Engineered Peptide Vectors for Targeted Delivery of Cytoskeleton Modulating Drugs in Ovarian Cancer.
2. Development of Long-Acting Peptide Dual Modulators for Treatment of Hypertension and End-Organ Protection.

Research Expertise

• Drug Delivery, Antimicrobial Resistance, Peptide Therapeutics, Bioactive Peptides, Combinatorial Therapy, Network Medicine, Personalized Medicine, Cancer Biomarkers