Dr. Rohini R Nair, PhD

About

I obtained my Ph.D. in Biotechnology from Banaras Hindu University, Varanasi. I am the recipient of competitive Marie-Curie Coinvest fellowship. I did my first postdoctoral research with Prof Marco Bianchi from the University of San Raffaele in Milan, Italy. Later I went to Weizmann Institute of Science, Rehovot, Israel to do another research training with Prof Jeffrey Gerst. During my academic training I have tackled many different problems, particularly in reproductive biology during my Ph.D. and chromatin & RNA biology during my postdoctoral training. I have always been willing to face the most diverse problems in order to gain a broad perspective in biology as well as to use cutting edge techniques to explore these problems. During my training, I have acquired substantial expertise in molecular and cellular biology, genetic engineering, identification of diagnostic marker. I intend to use my expertise to address the challenges of translational research for societal problems.

Background

• 2015 Ph.D Biotechnology Molecular Human Genetics Department, Banaras Hindu University, Varanasi
• 2008 M.Sc Biotechnology Pt. Ravishankar Shukla University, Raipur
• 2006 B.Sc Pt. Ravishankar Shukla University, Raipur

Honours and Awards

• Meritorious student award in Bachelor’s degree in 2006
• Meritorious student award in Master’s degree in 2008
• Council of Scientific Industrial Research –Junior Research Fellowship in200
• Department of Biotechnology- Junior Research Fellowship 2009
• Marie Curie Co-Invest Postdoctoral Research fellowship in 2014
• Swarn Kanta Dingle Award for excellent contribution in Reproductive Biology by Indian Council of Medical Research in 2017
• Arturo Falaschi ICGEB Fellowship 2018
• International PBC Fellowship 2018
• Ramanujan fellowship SERB 2022
• Ramalingaswami Re-entry fellowship 2022

Research Group Overview

• If we compare the cell and world one can find lot of similarity. Like how world is divided in continent and counties, cell is also organized in compartment. Travel of human is well regulated by border security in different countries similarly, the passage of molecules is well regulated in different compartment. Signature in molecule exist to travel from one compartment to another. Work in my lab is presently split into two main research efforts. First, we aim to look on RNA signature regulating the fate and function of mRNA. Our main focus will be to study the role of mRNA multiplexing (formation of transperon) formation of mRNP particle regulate the cell physiology. Moreover, motif (Riboswitches) can be also utilized to target drug or the RNA binding protein that bind to specific motif can be targeted. The second research effort will be to understand mRNA Ribosome heterogeneity that exist in cell for the biologic production.

Publications

• Rohini R. Nair, Gal Haimovich and Jeffrey E. Gerst. An Aptamer-based mRNA Affinity Purification Procedure (RaPID) for the Identification of Associated RNAs (RaPID-seq) and Proteins (RaPID-MS) in Yeast.Bio-protocol 2022;12.DOI:10.21769/BioProtoc.4274 (ImpactFactor: 5.7)
• Rohini R. Nair, Dimitry Zabezhinsky, Rita Gelin-Licht, Brian Haas, Michael C.A. Dyhr, Hannah S. Sperber, Chad Nusbaum, Jeffrey E. Gerst. Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology. eLife 2021;10:e66050 DOI: 10.7554/eLife.66050(Impact Factor: 8.1)
• Verma P, Verma R, Nair RR, Budhwar S, Khanna A, Agrawal NR, Sinha R, Birendra R, Rajender S, Singh K. (2019) Altered crosstalk of estradiol and progesterone with Myeloid-derived suppressor cells and Th1/Th2 cytokines in early miscarriage is associated with early breakdown of maternal-fetal tolerance. AmJ ReprodImmunol. 81(2):e13081.ISSN: 1046- 7408 (Impact Factor: 3.0)
• Nair RR, Mazza D, Gorzanelli A, Brambilla F, Agresti A and Bianchi ME (2018) LPS-challenged macrophages emit microvesicles coated with histones Front Immunol. 2018 Jun 27;9:1463. ISSN: 1664-3224 (Impact Factor: 7) 27/6/2018, 17734. 10.3389/fimmu.2018.01463