Dr. Subeer S. Majumdar

About

Dr. Subeer S. Majumdar has done his M.Sc. from Nagpur University and did his Ph.D. work at National Institute of Health & Family Welfare, New Delhi, India. Dr. Majumdar did his Postdoctoral Research at School of Medicine, Southern Illinois University, Carbondale, USA and at Department of Cell Biology and Physiology, University of Pittsburgh, USA. Dr. Majumdar was working at National Institute of Immunology, New Delhi and was former distinguished Professor & former Director National Institute of Animal Biotechnology, Hyderabad prior to assuming this responsibility.

Background

Education & Research

• 1989 Ph.D., Reproductive Biotechnology Using Sub human primates and rodents, Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Delhi (Registered at Nagpur University)
• 1989-1990 Fellow, Lalor Foundation, USA (with Dr. A Bartke), Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL USA
• 1990 Research Associate (with Dr. A Bartke), Department of Physiology, School of Medicine, Southern Illinois University, Carbondale, IL USA
• 1991-1994 Fellow, A W Mellon Foundation, USA (with Prof. T. M. Plant), Department of Cell Biology and Physiology, University of Pittsburgh, USA
• 1994-1997 Senior Project Associate (With Dr. G.P. Talwar), Division of Immuno-endocrinology (project on phase III contraceptive vaccine for human) National Institute of Immunology, New Delhi

Professional

• 2022-present Director General, Gujarat Biotechnology University (GBU), Government of Gujarat.
• 2022-2021 Distinguished Professor, National Institute of Animal Biotechnology (NIAB), Hyderabad.
• 2021-2016 Director, National Institute of Animal Biotechnology (NIAB), Hyderabad.
• 2016-2011 Staff Scientist VII, In charge, Embryo Biotechnology Lab, Cellular Endocrinology Lab, Primate Research Centre, National Institute of Immunology (NII), New Delhi.
• 2011-2007 Staff Scientist VI, In charge, Embryo Biotechnology Lab, Cellular Endocrinology Lab, Primate Research Centre, National Institute of Immunology (NII), New Delhi.
• 2007-2002 Staff Scientist V, In charge, Embryo Biotechnology Lab, Cellular Endocrinology Lab, Primate Research Centre, National Institute of Immunology (NII), New Delhi.
• 2002-1997 Staff Scientist IV, In charge, Cellular Endocrinology Lab, Primate Research Centre, National Institute of Immunology (NII), New Delhi.

Honours and Awards

Fellowships of Academies:

• Fellow: The National Academy of Sciences, Allahabad, 2009
• Fellow: Indian National Science Academy, Delhi, 2009
• Fellow: Indian Academy of Sciences, Bangalore, 2014

Other Awards:

• Prof. U. S. Srivastava memorial lecture award from National Academy of Sciences, India (NASI) (March, 2020).
• Bob Edward Oration Award for Studies of Functional Genomics, To Decipher New Factors which may Aid to generate Fertile Sperm, In cases of Idiopathic Male infertility at 8th International congress of ACE (July, 2019)
• The J.C. Bose Fellowship (March 2018) from SERB
• Manipal Association of Clinical Embryologists (MACE) Award 2016 for outstanding contribution to embryology (March 2017)
• Dr. NN Dastur Memorial Oration award awarded by the National Dairy reasearch Institute (February 2017).
• Dr. T. C. Anandkumar Gold Medal Oration award of Indian society for study of Reproduction and Fertility (Feb, 2014)
• Richard Masillamony Gold medal oration award, given by Indian Society for Veterinary immunology and Biotechnology (2013).
• P. Govindarajalu Gold medal oration award for Reproductive sciences by Society of Reproductive Biology and Cellular Endocrinology (2012).
• TATA INNOVATION Fellowship, Given by DBT for application oriented innovative research carried in India, (2011).
• National Academy of Science – Reliance Industries platinum Jubilee award for application oriented innovations in biological sciences, (2011).
• Labshetwar Award, Given by the Indian Society for study of Reproduction and fertility for population control, (2007).

Research Group Overview

Dr. Majumdar’s lab works in the field of animal biotechnology, genomics and animal reproduction. His present research focus lies in the field of…

• Production of therapeutic proteins for animal and human in milk of farmed animals.
• New Methods of transgenesis for biomedical research and to facilitate production of transgenic cattle, goat and buffalo. To increase the quality of the herd: disease resistant and more milk yielding animals.
• Livestock genomics.
• Alternative to knock out technology, utilizing shRNA to generate transgenic animals.

Publications

LIST OF 10 MOST SIGNIFICANT PUBLICATIONS IN last 5 years
1. Sridhar Kavela, Pallavi Vyas, Jusail, Sandeep K. Kushwaha, Subeer S. Majumdar, Syed M. Faisal. Use of an Integrated Multi-Omics Approach to Identify Molecular Mechanisms and Critical Factors Involved in the Pathogenesis of Leptospira. (Co-corresponding author). Microbiology Spectrum. 2023 https://doi.org/10.1128/spectrum.03135-22. IF 9.04
2. Neelam A. Topno , Veerbhan Kesarwani , Sandeep Kumar Kushwaha , Sarwar Azam , Mohammad Kadivella , Ravi Kumar Gandham and Subeer S. Majumdar. Non-Synonymous Variants in Fat QTL Genes Among High-and Low-Milk-Yielding Indigenous Breeds. Animals 2023, 13(5), 884; https://doi.org/10.3390/ani13050884. IF. 3.2
3. Goutam Ulgekar, Dilpreet Kaur, Venkateswaran Ganesan, Souvik Sen Sharma, Nirmalya Ganguli, Subeer S. Majumdar. Anhydride chemistry-based hexanoylation of polyethylenimine increases transfection efficiency and expression of tagged DNA for therapeutic proteins in cultured cells. Biotechnology and Bioengineering . 2022; 119:3275–3283. IF: 4.395
4. Alka Gupta, Amandeep Vats, Anindita Ghoshal, Kamal Mandal, Rajesh Sarkar, Indrashis Bhattacharya, Sanjeev Das, Rahul Pal, Subeer S Majumdar. Follicle Stimulating Hormone mediated decline in mir-92a-3p expression in pubertal Sertoli cells is crucial for germ cell differentiation and male fertility. Cell and Molecular Life Sciences , 2022 (in press) IF: 9.261
5. Alka Gupta, Kamal Mandal, Parminder Singh, Rajesh Sarkar, Subeer S Majumdar. Declining levels of mir-382-3p at puberty trigger the onset of spermatogenesis. Molecular Therapy: Nucleic Acids , 2021, 26, 192-207 IF: 10.183
6. Indrashis Bhattacharya, Souvik Sen Sharma, Hironmoy Sarkar, Alka Gupta, Subeer S Majumdar. FSH mediated cAMP signaling upregulates the expression of Gα subunits in pubertal rat Sertoli cells. Biochemical and Biophysical Research communications , 2021, 569, 100-105 IF: 3.575
7 Abhishek Das, Satarupa Dutta, Dewanshu Sharma, Amit pal, Nirmalya Ganguli, Subeer S Majumdar. An easy method for developing fusion enabled SARS CoV2 virus fusion mimic (SCFM), bypassing the need of Bio safety level (BSL) facility. Bioengineered , 2021, 12, 4407-4419 IF: 3.269
8. Rajesh Kumar Sarkar, Souvik Sen Sharma, Kamal Mandal, Neerja Wadhwa, Neetu Kunj, Alka Gupta, Rahul Pal, Umesh Rai. Subeer S. Majumdar. Homeobox transcription factor Meis1 is crucial to Sertoli cell mediated regulation of male fertility. Andrology . 2020, IF 4.456
9. Bhola Shankar Pradhan, Indrashis Bhattacharya, Rajesh Sarkar, Subeer S Majumdar. Pubertal down-regulation of tetraspanin-8 in testicular Sertoli cells is crucial for male fertility. Molecular Human Reproduction , 2020, 26, 760-772 IF: 4.5
10. Nirmalya Ganguli, Nilanjana Ganguli, Sunandini Chandra, Mayank Chaubey, Debi P. Sarkar and Subeer S. Majumdar. A Combinatorial Approach for Robust Transgene Delivery and Targeted Expression in Mammary Gland for Generating Biotherapeutics in milk, Bypassing Germline Gene Integration. Applied Microbiology and Biotechnology . 2018 Jul;102(14):6221-6234. doi: 10.1007/s00253-018-9094-2. IF: 5.560
11. Sayon Basu, Satya Pal Arya, Abul Usmani, Bhola Shankar Pradhan, Rajesh Kumar Sarkar, Nirmalya Ganguli, Mansi Shukla, Kamal Mandal, Surendra Singh, Kanchan Sarda, Subeer S Majumdar. Defective Wnt3 expression by testicular Sertoli cells compromise male fertility. Cell and Tissue Research , 2018, 371, 351-363 IF: 5.249

LIST OF 2 MOST IMPORTANT PAPERS in past
1. Suveera Dhup and Subeer S. Majumdar. Transgenesis via permanent integration of genes in repopulating spermatogonial cells in vivo. Nature Methods, 2008, 5(7):601-603. IF: 47.24
2. Durba Pal, Suman Dasgupta, Rakesh Kundu, Sudipta Maitra, Gobardhan Das, Satinath Mukhopadhyay, Sukanta Ray, Subeer S Majumdar & Samir Bhattacharya. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nature Medicine, 2012, 18(8):1279-1285. IF: 87.24